​​Dr. St. George has been with the New York Department of Health—Wadsworth Center for over two decades, as the Director of Virology since 2004 and Chief of the Laboratory of Viral Diseases (LVD) since 2008. She spearheaded operational enhancements, including robotic liquid handlers, automated extractors, bar-coding, and electronic data transfer. Consequently, Wadsworth was positioned to manage the surge response for the 2009 influenza pandemic, and subsequent major outbreaks.
With the emergence of drug-resistant influenza, she formed an Antiviral Resistance team in 2006, developing and validating methods for genotypic and phenotypic surveillance for resistant strains. The lab became the sole CDC-funded support laboratory for influenza drug resistance testing. In 2012, Dr. St. George led the development of a proficiency testing program for influenza molecular diagnosis, which was circulated to US public health and Department of Defense laboratories.
As Director of the Research and Development Group in Laboratory of Viral Diseases, Dr. St. George has investigated and developed numerous methods and platforms, including extensive applications of next generation sequencing. As a result, tens of thousands of viral sequences have been uploaded into public databases. With these data, her laboratories have developed the ability to track lines of importation and transmission during outbreaks.
Since 2012, Dr. St. George has led the Vaccine Preventable Diseases Reference Center in New York, and the National Influenza Reference Center in NY since 2015. In early 2021, she spearheaded the establishment of the New York State Sequencing Consortium, comprising laboratories at four major academic medical centers and Wadsworth. In 2022 the work was expanded to include wastewater testing. New methods and instruments were implemented for rapid automated sequencing at all sites, and a proficiency testing program was developed for sequence analysis in wastewater. She now serves as Scientific Director for the consortium.
Under Dr. St. George's direction and leadership, the virology laboratories at Wadsworth have developed over 100 methods for virus detection and characterization, including conventional and real-time PCR, Sanger-, pyro- and next generation sequencing, and specialty culture techniques for antiviral resistance and antibody neutralization. Many have been published in peer-reviewed literature or shared with other laboratories. Dr. St. George has authored or co-authored almost 200 publications, including 25 book chapters and reviews, and 150 papers in peer-reviewed literature. Approximately 125 of her papers cover work performed since moving to public health in 2004.
Through her APHL committee work, Dr. St. George has contributed to the development of guidance documents for best technical practices. Additionally, she was a member of the Lead Work Group for the National Influenza Surveillance Project, developing, writing and editing large sections of the Influenza Rightsize Roadmap with extensive sections on best technical practices.​​