Newborn Screening Sequencing Decision Matrix Summary
Use this matrix if you are considering adding second- or third-tier sequencing to your program.
Access the Matrix SummarySequencing Decision Matrix
As newborn screening programs consider adding complex molecular testing options, such as gene sequencing, many considerations and resource needs should be assessed to determine if, when and how to incorporate sequencing into their programs. Use our decision matrix tool to evaluate your options.
Questions?
Contact the Newborn Screening and Genetics team: [email protected]
What to Consider
Molecular Screening Implementation Considerations
Before implementing complex molecular testing options, such as gene sequencing, it is important to evaluate how a new workflow will impact your existing newborn screening program. Factors include personnel, follow-up, quality control and assurance, platform and workflow considerations, results analysis and other resource needs should be assessed to determine if, when and how to incorporate sequencing.
Understand Your Options
Sequencing Decision Matrix Tool
About the Decision Matrix
The Newborn Screening Sequencing Decision Matrix outlines implementation considerations and to help evaluate plans of action for the incorporation of gene sequencing in a screening algorithm. It provides custom recommendations so you can understand how existing laboratory workflows and processes will need to be adjusted.
The decision matrix begins at the second- or third-tier level of testing. It uses skip logic to provide custom recommendations based on answer selections, and users can view all decision points.
There are four sections of questions:
- Utility of sequencing
- Capability considerations
- Outsourcing
- General sequencing considerations
Using the Decision Matrix Tool
Use the summary document of implementation considerations to assess initial readiness, and as a companion to the tool as you work through the questions.
After working through all the questions, view and save or print a PDF version of your answers for reference.
Access the MatrixLearn More
Additional Sequencing Resources
Tiered Testing
Watch recordings of webinars hosted by the Molecular Subcommittee:
- Biochemical Second-tier Testing and Molecular Second- and Third-tier Testing Options and Considerations
- Designing a Tiered Testing Strategy
More on Molecular Screening
Find more information ​on available molecular methods and quality improvement activities, as well as additional resources for implementation and training: